krewersf's blog

Transfer of Montelukast into Human Milk During Lactation.

Montelukast is a commonly used drug in allergies,  and as you know, eveyone has allergies.  This data shows that levels in milk are really quite low (RID = 0.68)  and there is no obvious risk to a breastfeeding infant.  TWH


Title: Transfer of Montelukast into Human Milk During Lactation.

Authors: Datta P, Rewers-Felkins K, Baker T, Hale TW.

Transfer of methylprednisolone into breast milk in a mother with multiple sclerosis.

I always worry about HIGH doses of any drug.  We frequently receive calls from mothers undergoing 1000 mg IV doses of methylprednisolone for MS.

Transfer of natalizumab into breast milk in a mother with multiple sclerosis.

Natalizumab is a monoclonal antibody that is only used in humans with multiple sclerosis.  It is somewhat toxic, and we were interested to see if this large monoclonal antibody transfers into human milk.  Levels in milk appear low,  but I made a mistake in the timing of the study, and should have drawn milk levels several months longer.  I need to redo this study and go out to about 120 days.   However, at this point, I still think milk levels are subclinical.   TWH


Transfer of linezolid into breast milk.

This is one of the InfantRisk Centers studies.  We found that levels of linezolid in human milk are really low.  Good news if a mom needs this drug.   TWH


Title: Transfer of linezolid into breast milk.

Authors: Rowe HE, Felkins K, Cooper SD, Hale TW.

Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism.

All of us who work in pediatrics know that adequate thyroid function in a newborn is absolutely critical for the infants development.  Nothing is worse than hypothyroidism in a newborn infant.  While the infant needs low to modest levels of potassium iodine to make all the thyroxin it needs,  TOO MUCH iodine basically shuts the infant thyroid down.  Remember,  there is a pump in the human breast that collects all iodine molecules that pass the mothers breast and transfers that iodine molecule into the milk.  This was nature's way to make sure the baby could make

Persistence of Zika Virus in Breast Milk after Infection in Late Stage of Pregnancy.

This interesting article confirms what we've suggested for some time, that Zika virus is transferred into human milk. However,  should a mom with Zika stop breastfeeding,  apparently not,  no abnormalities were found in these infants.  TWH


Infant formulas containing hydrolysed protein for prevention of allergic disease.

Many of us have thought for some time that to avoid cows milk allergy in infants, we could avoid this problem by using the hydrolyzed infant formulas rather than the cows milk formulas.  Seems the evidence doesn't support this theory.  TWH


May mothers given warfarin breast-feed their infants?

This study further confirms what we've thought for some time,  that the Warfarin anticoagulant was safe to use in breastfeeding mothers.  TWH


Deep breast pain during lactation: a case-control study in Sweden investigating the role of Candida albicans.

One of the most consistent rumors in human lactation for the last 30 years, has been that sore nipples are often caused by Candia Albicans infections.  Several of us have published that his etiology of sore nipples is completely wrong,  but this "syndrome" continues to be discussed in the beastfeeding field.  This study below, again,  clearly suggests that Candida as a cause of sore nipples,  is wrong.  Sorry folks,  its something else.   TWH


The management of hypertension in women planning for pregnancy.

Nothing is more important for a fetus than the adequate control of blood pressure in the mom.  We are seeing hypertension more and more often today in pregnant women as the rate of obesity has risen.  This study reviews treatment of hypertension in pregnant women.  TWH