With respect to milk supply in women taking methylergonovine, we have found that a single post-partum dose will suppress prolactin levels, but doesn't seem to have much of a noticeable effect on supply. Existing studies are conflicted regarding this drug's effect on milk supply if used for more than a single post-partum dose. Some studies found no effect, others describe a very significant drop in milk production which is reversible on stopping the medication.1-4 No new research has been published on this topic in the last 20 years.
James Abbey, MD
1. Del Pozo E, Brun Del Re R, Hinselmann M. Lack of effect of methyl-ergonovine on postpartum lactation. American journal of obstetrics and gynecology. Dec 15 1975;123(8):845-846.
2. Perez-Lopez FR, Delvoye P, Denayer P, L'Hermite M, Roncero MC, Robyn C. Effect of methylergobasine maleate on serum gonadotrophin and prolactin in humans. Acta endocrinologica. Aug 1975;79(4):644-657.
3. Peters F, Lummerich M, Breckwoldt M. Inhibition of prolactin and lactation by methylergometrine hydrogenmaleate. Acta endocrinologica. Jun 1979;91(2):213-216.
4. Weiss G, Klein S, Shenkman L, Kataoka K, Hollander CS. Effect of methylergonovine on puerperal prolactin secretion. Obstetrics and gynecology. Aug 1975;46(2):209-210.